Project
Multiscale computations of memory consolidation: off-line replay and dopamine release during wakeful rest following encoding
The role of dopamine in consolidation events that fix information at synapses and allow transfer from one region to another is poorly understood. In this project, we will investigate the relationship between memory performance and dopamine-modulated hippocampal memory consolidation in young and old subjects using a monetary incentive delay task, multimodal neuroimaging and multiscale brain models. We will use several experimental and theoretical strategies to gain understanding into the neurocomputational mechanisms associated with hippocampal dopaminergic modulation and its changes during aging. Combining 7T high-field MRI, simultaneous MR−PET, multivariate pattern classification analysis and brain network modeling, we will study memory processes associated with offline replay of rewarding memories in relation to dopamine release and structural changes of ageing on multiple spatial and temporal scales.
Image Single-subject mean PET images overlaid on a T1 image. Courtesy of (Alex) Yeo Jin Yi
Team
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Prof Dr Emrah Düzel
Otto von Guericke - Universität Magdeburg
Director, Institute of Cognitive Neurology and Dementia Research
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Prof Dr med Petra Ritter
Charité – Universitätsmedizin Berlin
Head of the Section Brain Simulation (CCM)
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Dr Dorothea Hämmerer
Otto von Guericke - Universität Magdeburg
Head Hämmerer Lab
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Konstantin Bülau MD
Charité-Universitätsmedizin Berlin
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Alex (Yeo Jin) Yi
Otto von Guericke - Universität Magdeburg
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Aditya Nemali
Otto von Guericke - Universität Magdeburg
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Dr Jan Paul Triebkorn
Charité-Universitätsmedizin Berlin
(B06 Alumnus)
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Dr Matthew Betts
Otto-von-Guericke University Magdeburg
(B06 Alumnus)
Publications
Are unimanual movements bilateral?
Sabrina Chettouf, Laura M. Rueda-Delgado, Ralph de Vries, Petra Ritter, Andreas Daffertshofer
Neuroscience & Biobehavioral Reviews
The importance of standards for sharing of computational models and data
Russell A. Poldrack, Franklin Feingold, Michael J. Frank, Padraig Gleeson, Gilles de Hollander, Quentin JM Huys, Bradley C. Love, Christopher J. Markiewicz, Rosalyn Moran, Petra Ritter, Timothy T. Rogers, Brandon M. Turner, Tal Yarkoni, Ming Zhan, Jonathan D. Cohen
Computational Brain & Behavior
From genes to network models of Alzheimer’s disease: Biological framework for multi-scale brain simulation with The Virtual Brain
Leon Stefanovski, Jil Mona Meier, Roopa Pai, Paul Triebkorn, Tristram Lett, Leon Martin, Konstantin Bülau, Martin Hofmann-Apitius, Ana Solodkin, Anthony McIntosh, Petra Ritter
PsyArXiv
Movement disorders after hypoxic brain injury following cardiac arrest in adults
F. Scheibe, W. J. Neumann, C. Lange, M. Scheel, C. Furth, M. Köhnlein, P. Mergenthaler, J. Schultze‐Amberger, P. Triebkorn, P. Ritter, A. A. Kühn, A. Meisel
European Journal of Neurology
Dynamic functional connectivity between order and randomness and its evolution across the human adult lifespan
Demian Battaglia, Thomas Boudou, Enrique C. A. Hansen, Diego Lombardo, Sabrina Chettouf, Andreas Daffertshofer, Anthony R. McIntosh, Joelle Zimmermann, Petra Ritter, Viktor Jirsa
NeuroImage
Brain network simulations indicate effects of neuregulin-1 genotype on excitation-inhibition balance in cortical dynamics
Pedro Costa Klein, Ulrich Ettinger, Michael Schirner, Petra Ritter, Dan Rujescu, Peter Falkai, Nikolaos Koutsouleris, Lana Kambeitz-Ilankovic, Joseph Kambeitz
Cerebral Cortex
The importance of cerebellar connectivity on simulated brain dynamics
Fulvia Palesi, Roberta Maria Lorenzi, Claudia Casellato, Petra Ritter, Viktor Jirsa, Claudia A.M. Gandini Wheeler-Kingshott and Egidio D’Angelo
Frontiers in Cellular Neuroscience
Identifying optimal working points of individual Virtual Brains: A large-scale brain network modelling study
Paul Triebkorn, Joelle Zimmermann, Leon Stefanovski, Dipanjan Roy, Ana Solodkin, Viktor Jirsa, Gustavo Deco, Michael Breakspear, Anthony Randal McIntosh, Petra Ritter
bioRxiv
Noradrenergic-dependent functions are associated with age-related locus coeruleus signal intensity differences
Kathy Y Liu, Rogier A Kievit, Kamen A Tsvetanov, Matthew J Betts, Emrah Düzel, James B Rowe, Cam-CAN, Robert Howard and Dorothea Hämmerer
Nature Communications
Dynamic functional connectivity between order and randomness and its evolution across the human adult lifespan
Demian Battaglia, Thomas Boudou, Enrique CA Hansen, Diego Lombardo, Sabrina Chettouf, Andreas Daffertshofer, Anthony R McIntosh, Joelle Zimmermann, Petra Ritter, Viktor Jirsa
Neuroimage