Brain simulation as a cloud service: The Virtual Brain on EBRAINS

Michael Schirner, Lia Domide, Dionysios Perdikis, Paul Triebkorn,Leon Stefanovski, Roopa Pai, Paula Prodan, Bogdan Valean, Jessica Palmer, Chloê Langford, André Blickensdörfer, Michiel van der Vlag, Sandra Diaz-Pier, Alexander Peyser, Wouter Klijn, Dirk Pleiter , Anne Nahm, Oliver Schmid, Marmaduke Woodman, Lyuba Zehl, Jan Fousek, Spase Petkoski, Lionel Kusch, Meysam Hashemi, Daniele Marinazzo, Jean-François Mangin, Agnes Flöel, Simisola Akintoye, Bernd Carsten Stahl, Michael Cepic, Emily Johnson, Gustavo Deco, Anthony R. McIntosh, Claus C. Hilgetag, Marc Morgan, Bernd Schuller, Alex Upton, Colin McMurtrie, Timo Dickscheid, Jan G. Bjaalie, Katrin Amunts, Jochen Mersmann, Viktor Jirsa, Petra Ritter

The Virtual Brain (TVB) is now available as open-source services on the cloud research platform EBRAINS ( It offers software for constructing, simulating and analysing brain network models including the TVB simulator; magnetic resonance imaging (MRI) processing pipelines to extract structural and functional brain networks; combined simulation of large-scale brain networks with small-scale spiking networks; automatic conversion of user-specified model equations into fast simulation code; simulation-ready brain models of patients and healthy volunteers; Bayesian parameter optimization in epilepsy patient models; data and software for mouse brain simulation; and extensive educational material. TVB cloud services facilitate reproducible online collaboration and discovery of data assets, models, and software embedded in scalable and secure workflows, a precondition for research on large cohort data sets, better generalizability, and clinical translation.

NeuroImage. 251:118973 (2022)


brain modellingcloudconnectomehigh performance computingnetwork modelneuroimaging
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