Project
Contextual modulation of spatial memory consolidation
The proposed project investigates contextual factors that may determine the relative contributions of hippocampus and neocortex within networks for spatial memory consolidation. Our central hypothesis is that availability of previous spatial knowledge critically determines hippocampal-neocortical interactions during systems consolidation. In four work packages (WPs), we will combine electrophysiological, pharmacological, imaging and lesion approaches in human patients and normal human subjects. In WP 1, we will study schema effects on ripples recorded from the human medial temporal lobe and neocortex. In WP 2, we will study whether early memory consolidation of schema-congruent and -incongruent information show a differential susceptibility to transient modulation of hippocampal activity with the anesthetic propofol. In WP3, we will study how contextual information modifies consolidation of spatial information acquired during free navigation. In WP 4, we will study how the availability of remote spatial memory facilitates consolidation of spatial memoranda independently from the hippocampus.
Image Navigation task setting. Source, Jürgen Hohmuth
Team
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Prof Dr med Christoph Ploner
Charité-Universitätsmedizin Berlin
Head Brain & Behaviour
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Prof Dr med Carsten Finke
Charité-Universitätsmedizin Berlin
Head Cognitive Neurology Lab
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Dr Deetje Iggena
Charité-Universitätsmedizin Berlin
B05 Postdoc
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Patrizia Maier
Charité – Universitätsmedizin Berlin
B05 PhD
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Jan Martin
(B05 Alumnus) Student helper 2020-2022
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T. Bothe
(B05 Alumnus/Alumna) Student helper 2019
Publications
Post-encoding modulation of spatial memory consolidation by propofol
Deetje Iggena, Patrizia M. Maier, Sophia M. Häußler, Mario Menk, Heidi Olze, Matthew E. Larkum, Carsten Finke, Christoph J. Ploner
Cortex 156, 1-12 (2022)
Musical expertise shapes visual-melodic memory integration
Martina Hoffmann, Alexander Schmidt, Christoph J. Ploner
Front. Psychol. 13:973164 (2022)
Long-term cognitive outcome in anti-nmdA receptor encephalitis
Josephine Heine, Ute A. Kopp, Johanna Klag, Christoph J. Ploner, Harald Prüss, Carsten Finke
Ann Neurol 90:949–961 (2021)
State-dependent signatures of anti-NMDA-receptor encephalitis: a dynamic functional connectivity study
Nina von Schwanenflug, Stephan Krohn, Josephine Heine, Friedemann Paul, Harald Prüss, Carsten Finke
bioRxiv
Transdiagnostic hippocampal damage patterns in neuroimmunological disorders
Josephine Heine, Harald Prüß, Michael Scheel, Alexander U. Brandt, Stefan M. Gold, Thorsten Bartsch, Friedemann Paul, Carsten Finke
NeuroImage: Clinical. 28:102515 (2020)
Early volumetric changes of hippocampus and medial prefrontal cortex following medial temporal lobe resection.
Anna Pajkert, Christoph J Ploner, Thomas-Nicolas Lehmann, Veronica A Witte, Frank Oltmanns, Werner Sommer, Martin Holtkamp, Hauke R Heekeren, Carsten Finke
Eur J Neurosci. 52(10):4375-4384 (2020)
Propofol modulates early memory consolidation in humans
Daa Un Moon, Nazli Esfahani-Bayerl, Carsten Finke, Daniel J Salchow, Mario Menk, Simon Bayerl, Richard Kempter and Christoph J Ploner
eNeuro. 7(3):ENEURO.0537-19.202
Integrating across memory episodes: developmental trends
Yee Lee Shing , Carsten Finke, Martina Hoffmann, Anna Pajkert, Hauke R Heekeren and Christoph J Ploner
PLoS One. 14(4):e0215848 (2019)
Disentangling hippocampal and amygdala contribution to human anxiety-like behaviour
Dominik R Bach, Martina Hoffmann, Carsten Finke, Rene Hurlemann and Christoph J Ploner
J Neurosci. 39 (43): 8517-8526 (2019)