B05

Schema-modulated consolidation of spatial memories: From single cells to large-scale networks in humans

In this project, we will employ diverse neuroscientific techniques to uncover key processes involved in the early (<24h) consolidation of spatial memories in humans, and we will identify how these processes are modulated by schemas. In WP1, we will perform human single-neuron recordings in epilepsy patients performing a supermarket navigation task, allowing us to test for cells that encode items, contexts, and schemas, respectively. In WP2, we will record intracranial EEG in epilepsy patients performing the same task to identify neural oscillations involved in consolidating schema-congruent versus schema-incongruent spatial memories, including hippocampal and prefrontal ripple oscillations. In WP3, we will use the GABAergic anesthetic propofol to examine the effects of transient hippocampal dysfunction on schema-dependent consolidation. In WP4, we will study the effects of persistent hippocampal damage on spatial memory consolidation in individuals with hippocampal lesions. Together, this work will provide fundamental insights into neural processes underlying spatial memory consolidation in humans and reveal how they are shaped by pre-existing knowledge.

Image Navigation task setting. Source, Jürgen Hohmuth

Archive – B05 (SFB1315/1)

Archive – B05 (SFB1315/2)

 

Graphical Abstract

Graphical abstract: (A) Conceptual Framework. PFC, prefrontal cortex; HC, hippocampus; TL, temporal lobe. (B) Example of a virtual supermarket. (C) Schema-modulated spatial memory task. Different cohorts of participants (epilepsy patients, individuals with brain lesions, healthy adults) will complete a virtual-reality task where they learn and recall locations of items in different supermarkets sharing the same geometrical layout. Schema-congruent items (gray) will be in accordance with their typical location in supermarkets; schema-incongruent items (white) will be in discordance with their typical location. We predict that, during rest periods between task sessions, neural consolidation processes will occur, particularly during ripples.

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