B06

Content-dependent consolidation of autobiographical memories: Investigating brainstem-hippocampal-cortical interactions with layer-specific resolution

The second funding period has allowed us to establish the assessment of functional large-scale network changes as well as structural engram-related plasticity during memory consolidation with unprecedented resolution in ultra-high field MR imaging in humans. In the following funding period, this approach will be extended towards investigating network dynamics at the individual level in the context of the recollection and consolidation of autobiographical memories over different time intervals. Our approach will provide information on how engram-related networks for different types of autobiographic content (i.e., spatial, social, emotional), and temporal distance change over time. Additionally, we will compare the consolidation of recent true and false autobiographical memories. In doing so, we will build on our investigations from the first and second funding period on emotional memories and the role of neuromodulatory circuits in consolidation. Ultrahigh-field imaging with our unique 7T Connectome MR will allow us to investigate these questions with unprecedented spatial resolution and sensitivity. A particular focus in this funding period will be the characterization of autobiographical memory consolidation at the individual level with precision mapping. To this end, we will acquire data with high sampling intensity, that is, with repeated assessments within individuals. As in the previous funding period, the impact of sleep quality on memory consolidation will be additionally assessed.

Image Single-subject mean PET images overlaid on a T1 image. Courtesy of Yeo Jin Yi

Archive – B06 (SFB1315/1)

Archive – B06 (SFB1315/2)

Graphical Abstract

Graphical Abstract. AIM, Left: Outline of relevant assumed layer- and subfield specific connections in memory network. DESIGN, METHOD, Right: Schematic overview of experimental design in the third funding period. High density sampling on ultra-highfield imaging will be used to investigate individual-specific connectivities during the recollection of autobiographical memories of different contents.

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