Project
A combined perturbation and modelling approach to understand and modulate the interactions between brain oscillations underlying memory consolidation in human NREM sleep
We combine experimental work in human subjects with computational modelling of neurophysiological events, which correlate with and possibly underlie sleep-dependent memory consolidation in humans. Our main goals are to mechanistically understand the spatiotemporal patterns of slow oscillations, δ-waves, spindle, and sharp-wave ripple activity, to infer mechanisms of spatially distributed systems memory consolidation underlying the observed spatiotemporal patterns, to mechanistically understand and predict the impact of transcranial current stimulation on these oscillatory events, and to design efficient stimulation protocols for manipulating those patterns.
Image Time frequency representation (TFR) in the frequency range of 5 to 20 Hz for SO (left) and delta (right) events. Courtesy of B03 members
Team
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Prof Dr Klaus Obermayer
Technische Universität Berlin & BCCN
Head Neural Information Processing Group
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Prof Dr Agnes Flöel
Universitätsmedizin Greifswald
Chair, Department of Neurology
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Prof Dr med Petra Ritter
Charité – Universitätsmedizin Berlin
Head of the Section Brain Simulation (CCM)
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Dr Nikola Jajcay
Technische Universität Berlin
B03 Associate Postdoc
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Dr Jeffrey Scott Hanna
Universitätsmedizin Greifswald
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Dr Julia Ladenbauer
Universitätsmedizin Greifswald
B03 Associate Postdoc
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Dr Daniela Obst
Universitätsmedizin Greifswald
B03 Associate Postdoc
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Caglar Cakan
Technische Universität Berlin
B03 PhD
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Robert Malinowski
Universitätsmedizin Greifswald
B03 PhD
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Ronja Strömsdörfer
Technische Universität Berlin
B03 Associate PhD
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Cristiana Dimulescu
Technische Universität Berlin
B03 Associate PhD
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Liliia Khakimova
Universitätsmedizin Greifswald
B03 Associate PhD
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Jessica Uhrich
(B03 Alumna) Student helper 2018-2019
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Buse Dikici
Universitätsmedizin Greifswald
B03 Associate PhD (AG Flöel)
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Kateryna Yarova
(B03 Alumna) Student helper 2018-2019
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Larissa Stange
(B03 Alumna) Student helper 2020
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Sara Kriszik
(B03 Alumna) Student helper 2019-2020
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Melanie Marita Krüger
Universitätsmedizin Greifswald
B03 PhD (AG Flöel)
Publications
Spatiotemporal patterns of adaptation-induced slow oscillations in a whole-brain model of slow-wave sleep
Caglar Cakan, Cristiana Dimulescu, Liliia Khakimova, Daniela Obst, Agnes Flöel, Klaus Obermayer
Front Comput Neurosci. 15:800101 (2022)
Memory-relevant nap sleep physiology in healthy and pathological aging
Julia Ladenbauer, Josef Ladenbauer, Nadine Külzow, Agnes Flöel
Sleep. 44(7):zsab002 (2021)
Towards optimization of oscillatory stimulation during sleep
Julia Ladenbauer, Liliia Khakimova, Robert Malinowski, Daniela Obst, Eric Tönnies, Daria Antonenko, Klaus Obermayer, Jeff Hanna, Agnes Flöel
bioRxiv (2021)
Interrelations between delta waves, spindles and slow oscillations in human NREM sleep and their functional role in memory
Larissa N. Wüst, Daria Antonenko, Robert Malinowski, Liliia Khakimova, Ulrike Grittner, Klaus Obermayer, Julia Ladenbauer, Agnes Flöel
bioRxiv
Applications of optimal nonlinear control to a whole-brain network of FitzHugh-Nagumo oscillators
Teresa Chouzouris, Nicolas Roth, Caglar Cakan, Klaus Obermayer
Phys Rev E. 104(2-1):024213 (2021)
Cross-frequency slow oscillation–spindle coupling in a biophysically realistic thalamocortical neural mass model
Nikola Jajcay, Caglar Cakan, Klaus Obermayer
Front. Comput. Neurosci. 16:769860 (2022)
Brain simulation as a cloud service: The Virtual Brain on EBRAINS
Michael Schirner, Lia Domide, Dionysios Perdikis, Paul Triebkorn,...., Agnes Flöel, ...Jochen Mersmann, Viktor Jirsa, Petra Ritter
NeuroImage. 251:118973 (2022)
Virtual deep brain stimulation: Multiscale co-simulation of a spiking basal ganglia model and a whole-brain mean field model with The Virtual Brain
Jil M. Meier, Dionysios Perdikis, André Blickensdörfer, Leon Stefanovski, Qin Liu, Oliver Maith, Helge Ü. Dinkelbach, Javier Baladron, Fred H. Hamker, Petra Ritter
Exp Neurol. 354:114111 (2022)
Inter-individual and age-dependent variability in simulated electric fields induced by conventional transcranial electrical stimulation
Daria Antonenko, Ulrike Grittner, Guilherme Saturnino, Till Nierhaus, Axel Thielscher, Agnes Flöel
NeuroImage. 224: 117413 (2021)
Neurolib: A simulation framework for whole-brain neural mass modeling
Caglar Cakan, Nikola Jajcay, Klaus Obermayer
Cogn Comput. 1158(31) (2021)
Cognitive training and brain stimulation in prodromal Alzheimer’s disease (AD-Stim)—study protocol for a doubleblind randomized controlled phase IIb (monocenter) trial
Friederike Thams, Anna Kuzmina, Malte Backhaus, Shu-Chen Li, Ulrike Grittner, Daria Antonenko and Agnes Flöel
Alzheimer’s Res Ther. 12(1):142 (2020)
Biophysically grounded mean-field models of neural populations under electrical stimulation
Caglar Cakan and Klaus Obermayer
PLoS Comput Biol. 16(4):e1007822 (2020)
Weight loss reduces head motion: re-visiting a major confound in neuroimaging
Frauke Beyer, Kristin Prehn, Katharina A Wüsten, Arno Villringer, Jürgen Ordemann, Agnes Flöel, A Veronica Witte
Hum Brain Mapping. 41(9):2490-2494 (2020)
Cross-reactivity as a mechanism linking infections in stroke
Guglielmo Lucchese, Agnes Flöel, Benjamin Stahl
Front Neurol. 10:469 (2019)
