Project
A neuronal basis for systems memory consolidation
The hippocampus plays a critical role in the acquisition and consolidation of explicit memory. The dependence of declarative memories on the hippocampus decays over a time scale of weeks to years, and memories can eventually become independent of the hippocampus. This property has sparked the hypothesis of systems memory consolidation, which holds that the hippocampus guides a redistribution of memory engrams from the hippocampus towards neocortical networks over time. Although this process seems to be related to resting and/or sleep states and probably involves characteristic activity patterns that replay recent experiences (Girardeau et al., 2009; Diekelmann and Born, 2010), the synaptic and network plasticity mechanisms that underlie this memory transfer are unclear. The aim of the project presented here is to develop and test a mechanistic theory that could provide a neuronal basis for systems memory consolidation.
Image Modelling long-term memory consolidation (LTP, long-term potentiation, LTD, long-term depression). Created by Denis Alevi
Team
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Prof Dr Richard Kempter
Humboldt-Universität zu Berlin
Deputy Spokesperson, Head Theoretical Neuroscience Lab
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Prof Dr Henning Sprekeler
Technische Universität Berlin
Head Sprekeler Lab
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Dr Tiziano D’Albis
Humboldt-Universität zu Berlin
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Naomi Auer
Humboldt-Universität zu Berlin
PhD B01
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Denis Alevi
Technische Universität Berlin
PhD B01
Publications
Hebbian plasticity in parallel synaptic pathways: A circuit mechanism for systems memory consolidation
Michiel Remme, Urs Bergmann, Denis Alevi, Susanne Schreiber, Henning Sprekeler, Richard Kempter
PLOS Comput Biol 17(12):e1009681 (2021)
A neural code for egocentric spatial maps in the human medial temporal lobe
Lukas Kunz, Armin Brandt, Peter C. Reinacher, Bernhard P. Staresina, Eric T. Reifenstein, Christoph T. Weidemann, Nora A. Herweg, Ansh Patel, Melina Tsitsiklis, Richard Kempter, Michael J. Kahana, Andreas Schulze-Bonhage, Joshua Jacobs
Neuron. 109(17) 2781-2796.e10 (2021)
Microcircuits for spatial coding in the medial entorhinal cortex
John J Tukker, Prateep Beed, Michael Brecht, Richard Kempter, Edvard I Moser, and Dietmar Schmitz
Physiol Rev. 102:653–688 (2022)
Synaptic learning rules for sequence learning
Eric T. Reifenstein, Ikhwan Bin Khalid, Richard Kempter
eLife. 10:e67171 (2021)
Learning accurate path integration in a ring attractor model of the head direction system
Pantelis Vafidis, David Owald, Tiziano D'Albis, Richard Kempter
bioRxiv
Propofol modulates early memory consolidation in humans
Daa Un Moon, Nazli Esfahani-Bayerl, Carsten Finke, Daniel J Salchow, Mario Menk, Simon Bayerl, Richard Kempter and Christoph J Ploner
eNeuro. 7(3):ENEURO.0537-19.202
Recurrent amplification of grid-cell activity
Tiziano D'Albis and Richard Kempter
Hippocampus. 30(12):1268-1297 (2020)