Homeostatic presynaptic plasticity in memory consolidation and sleep of the aging brain

Plastic processes promote memory processes by driving synapses away from equilibrium, while homeostatic plasticity resets them. Sleep is considered key for resetting, but is also involved in memory consolidation, and changes with age. In Drosophila brains we described a homeostatic form of presynaptic plasticity (PreScale) connecting sleep deprivation, homeostatic sleep drive and memory consolidation. We here address the circuit implementation of PreScale and study the protective effects of PreScale at physiological and biochemical levels. Our results will deepen our understanding of how presynaptic plasticity operates between sleep, memory consolidation and aging.

Archive – A08 (SFB1315/1)



Participating Institutions