A08
Homeostatic presynaptic plasticity in memory consolidation and sleep of the aging brain
Plastic processes promote memory processes by driving synapses away from equilibrium, while homeostatic plasticity resets them. Sleep is considered key for resetting, but is also involved in memory consolidation, and changes with age. In Drosophila brains we described a homeostatic form of presynaptic plasticity (PreScale) connecting sleep deprivation, homeostatic sleep drive and memory consolidation. We here address the circuit implementation of PreScale and study the protective effects of PreScale at physiological and biochemical levels. Our results will deepen our understanding of how presynaptic plasticity operates between sleep, memory consolidation and aging.
Graphical Abstract
Graphical abstract: A08 investigates the principal connection between sleep and memory consolidation in the aging Drosophila brain. PreScale seemingly operates as global protective presynaptic mechanism connecting these entities.
Team
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Prof Dr Stephan Sigrist
Freie Universität Berlin
Head Sigrist Lab (FU & Charité Berlin)
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Dr Oriane Turrel
Freie Universität Berlin
A08 Postdoc
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Dr Torsten Götz
Freie Universität Berlin
A08 Postdoc (AG Sigrist)
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Dr Sheng Huang
Freie Universität Berlin
A08 Associate Postdoc
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David Toppe
Freie Universität Berlin
A08 PhD
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Dr Lisa Scheunemann
Freie Universität Berlin
Associate PI (Affiliated A08 AG Sigrist)
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Dr Raquel Suarez Grimalt
Freie Universität Berlin
A08 Associate Postdoc (AG Scheunemann)
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Anja Krivograd
Freie Universität Berlin
A08 Associate PhD
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Dr Yongtian Liang
Freie Universität Berlin
A08 Alumnus
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Audrey Bonitz
Freie Universität Berlin
Student helper 2019-2020 - A08 Alumna
Publications
Coupling of mitochondrial state with active zone plasticity in early brain aging
Lu Fei, Yongtian Liang, Ulrich Kintscher, Stephan J. Sigrist
Redox Biol. 79:103454 (2025)
Blobby is a synaptic active zone assembly protein required for memory in Drosophila
Lützkendorf J, Matkovic-Rachid T, Liu S, Götz T, Gao L, Turrel O, Maglione M, Grieger M, Putignano S, Ramesh N, Ghelani T, Neumann A, Gimber N, Schmoranzer J, Stawrakakis A, Brence B, Baum D, Ludwig K, Heine M, Mielke T, Liu F, Walter AM, Wahl MC, Sigrist SJ
Nat Commun. 16(1):271 (2025)
A brain-wide form of presynaptic active zone plasticity orchestrates resilience to brain aging in Drosophila
Sheng Huang, Chengji Piao, Christine B. Beuschel, Zhiying Zhao, Stephan J. Sigrist
PLoS Biol 20(12): e3001730 (2022)
Homeostatic active zone remodeling consolidates memories in the Drosophila mushroom body
Oriane Turrel, Niraja Ramesh, Marc J.F. Escher, Stephan J. Sigrist
bioRxiv (2021)
Postsynaptic plasticity of cholinergic synapses underlies the induction and expression of appetitive and familiarity memories in Drosophila
Carlotta Pribbenow, Yi-chun Chen, Michael-Marcel Heim, Desiree Laber, Silas Reubold, Eric Reynolds, Isabella Balles, Tania Fernández-d.V. Alquicira, Raquel Suárez-Grimalt, Lisa Scheunemann, Carolin Rauch, Tanja Matkovic, Jörg Rösner, Gregor Lichtner, Sridhar R Jagannathan, David Owald
eLife. 11:e80445 (2022)
Presynaptic and postsynaptic long-term plasticity in sleep homeostasis
Sheng Huang, Stephan J. Sigrist
Curr Opin Neurobiol. 69:1-10 (2021)
Unc13A and Unc13B contribute to the decoding of distinct sensory information in Drosophila
Atefeh Pooryasin , Marta Maglione , Marco Schubert, Tanja Matkovic-Rachid, Sayed-mohammad Hasheminasab, Ulrike Pech, André Fiala, Thorsten Mielke, Stephan J. Sigrist
Nat Commun. 12(1):1932 (2021)
Recruitment of release sites underlies chemical presynaptic potentiation at hippocampal mossy fiber boutons
Marta Orlando, Anton Dvorzhak, Felicitas Bruentgens, Marta Maglione, Benjamin R. Rost, Stephan J. Sigrist, Jörg Breustedt, Dietmar Schmitz
PLoS Biol. 19(6):e3001149 (2021)
eIF5A-hypusination, boosted by dietary spermidine, protects from premature brain aging and mitochondrial dysfunction
YongTian Liang, Chengji Piao, Christine B. Beuschel, David Toppe, Laxmikanth Kollipara, Boris Bogdanow, ..... Stephan J. Sigrist
Cell Rep. 35(2):108941 (2021)
The Unc13A isoform is important for phasic release and olfactory memory formation at mushroom body synapses
Jennifer Woitkuhn, Anatoli Ender, Christine B Beuschel, Marta Maglione, Tanja Matkovic-Rachid, Sheng Huang, Martin Lehmann, Joerg RP Geiger & Stephan J Sigrist
J Neurogenet. 34(1):106-114 (2020)
Presynaptic activity zone plasticity encodes sleep need in Drosophila
Sheng Huang, Chengji Pia, Christine B Beuschel, Torsten Götz, Stephan J Sigrist
Curr Biol. 30(6):1077-1091.e5 (2020)
Network-specific synchronization of electrical slow-wave oscillations regulates sleep drive in Drosophila
Davide Raccuglia, Sheng Huang, Anatoli Ender, M.-Marcel Heim, Desiree Laber, Raquel Suárez-Grimalt, Agustin Liotta, Stephan J Sigrist, Jörg RP Geiger, David Owald
Curr Biol. 29(21):3611-3621.e3 (2019)
Emerging concepts and functions of autophagy as a regulator of synaptic components and plasticity
Yongtian Liang
Cells. 8(1):34 (2019)
Autophagy within the mushroom body protects from synapse aging in a non-cell autonomous manner
Anuradha Bhukel, Christine B Beuschel, Marta Maglione, Martin Lehmann, Gabor Juhász, Frank Madeo and Stephan J Sigrist
Nat Commun. 10(1):1318 (2019)
