A07
Basis for consolidating place memories in Drosophila

In the second funding period, this project investigated how neural and network activity in the mushroom bodies influences olfactory associative memory consolidation in Drosophila. We also investigated neural activity underlying sleep regulation and molecular plasticity in the initial memory consolidation phase. We now aim at using our protocols developed in the last funding periods to investigate place memory consolidation in the central complex, which should further facilitate cross-species comparison.
Image Flies in vial (l) and magenta-stained mushroom body (r). Courtesy of Eric Reynolds
Graphical Abstract

Team
-
Prof Dr David Owald
Charité – Universitätsmedizin Berlin
Head Owald Lab
-
Dr Eric Reynolds
Charité-Universitätsmedizin Berlin
A07 Postdoc
-
Dr Sridhar Jagannathan
Charité – Universitätsmedizin Berlin
A07 Associate Postdoc
-
Desiree Laber
Charité-Universitätsmedizin Berlin
A07 Associate PhD alumna
-
Tania Fernandez del Valle Alquicira
Charité-Universitätsmedizin Berlin
A07 Associated PhD (Student helper 2019-2022)
-
Lara Dreide
Charité – Universitätsmedizin Berlin
Student helper 2019, 2022-2024 - A07
-
Isabella Balles
Charité – Universitätsmedizin Berlin
Student helper 2019 - A07 Alumna
Publications
Network synchrony creates neural filters promoting quiescence in Drosophila
Davide Raccuglia, Raquel Suárez-Grimalt, Laura Krumm, Anatoli Ender, Cedric B Brodersen, Sridhar R. Jagannathan, Martin Freire Krück, Niccolò P Pampaloni, Carolin Rauch, York Winter, Genevieve Yvon-Durocher, Richard Kempter, Jörg RP Geiger, David Owald
Nature 646:667–675 (2025)
Skewing information flow through pre- and postsynaptic plasticity in the mushroom bodies of Drosophila
Carlotta Pribbenow, David Owald
Learn Mem. 31(5):a053919 (2024)
Mating proximity blinds threat perception
Laurie Cazalé-Debat, Lisa Scheunemann, Megan Day, Tania Fernandez-d.V. Alquicira, Anna Dimtsi, Youchong Zhang, Lauren A. Blackburn, Charles Ballardini, Katie Greenin-Whitehead, Eric Reynolds, Andrew C. Lin, David Owald & Carolina Rezaval
Nature. 634, 635–643 (2024)
Calcium-permeable channelrhodopsins for the photocontrol of calcium signalling
Rodrigo G. Fernandez Lahore, Niccolò P. Pampaloni, Enrico Peter, M.-Marcel Heim, Linda Tillert, Johannes Vierock, Johannes Oppermann, Jakob Walther, Dietmar Schmitz, David Owald, Andrew J. R. Plested, Benjamin R. Rost, Peter Hegemann
Nat Commun. 13:7844 (2022)
Postsynaptic plasticity of cholinergic synapses underlies the induction and expression of appetitive and familiarity memories in Drosophila
Carlotta Pribbenow, Yi-chun Chen, Michael-Marcel Heim, Desiree Laber, Silas Reubold, Eric Reynolds, Isabella Balles, Tania Fernández-d.V. Alquicira, Raquel Suárez-Grimalt, Lisa Scheunemann, Carolin Rauch, Tanja Matkovic, Jörg Rösner, Gregor Lichtner, Sridhar R Jagannathan, David Owald
eLife. 11:e80445 (2022)
Learning accurate path integration in a ring attractor model of the head direction system
Pantelis Vafidis, David Owald, Tiziano D'Albis, Richard Kempter
eLife 11:e69841 (2022)
Network-specific synchronization of electrical slow-wave oscillations regulates sleep drive in Drosophila
Davide Raccuglia, Sheng Huang, Anatoli Ender, M.-Marcel Heim, Desiree Laber, Raquel Suárez-Grimalt, Agustin Liotta, Stephan J Sigrist, Jörg RP Geiger, David Owald
Curr Biol. 29(21):3611-3621.e3 (2019)
