Prof Dr Stephan Sigrist

Head Sigrist Lab (FU & Charité Berlin)

Freie Universität Berlin
Institut für Biologie / Genetik
Takustraße 6
14195 Berlin

Charité-Universitätsmedizin Berlin
Charité Campus Mitte
CharitéCrossOver (CCO)
AG Prof. Dr. Stephan Sigrist, 5. Ebene
Charitéplatz 1
10117 Berlin

+49-(0)30-83856940

Projects

A08

Homeostatic presynaptic plasticity in memory consolidation and sleep of the aging brain

Publications

Homeostatic active zone remodeling consolidates memories in the Drosophila mushroom body
Oriane Turrel, Niraja Ramesh, Marc J.F. Escher, Stephan J. Sigrist

bioRxiv (2021)
Presynaptic and postsynaptic long-term plasticity in sleep homeostasis
Sheng Huang, Stephan J. Sigrist
Curr Opin Neurobiol. 69:1-10 (2021)
Recruitment of release sites underlies chemical presynaptic potentiation at hippocampal mossy fiber boutons
Marta Orlando, Anton Dvorzhak, Felicitas Bruentgens, Marta Maglione, Benjamin R. Rost, Stephan J. Sigrist, Jörg Breustedt, Dietmar Schmitz
PLoS Biol. 19(6):e3001149 (2021)
Unc13A and Unc13B contribute to the decoding of distinct sensory information in Drosophila
Atefeh Pooryasin , Marta Maglione , Marco Schubert, Tanja Matkovic-Rachid, Sayed-mohammad Hasheminasab, Ulrike Pech, André Fiala, Thorsten Mielke, Stephan J. Sigrist
Nat Commun. 12(1):1932 (2021)
eIF5A-hypusination, boosted by dietary spermidine, protects from premature brain aging and mitochondrial dysfunction
YongTian Liang, Chengji Piao, Christine B. Beuschel, David Toppe, Laxmikanth Kollipara, Boris Bogdanow, ..... Stephan J. Sigrist
Cell Rep. 35(2):108941 (2021)
The Unc13A isoform is important for phasic release and olfactory memory formation at mushroom body synapses
Jennifer Woitkuhn, Anatoli Ender, Christine B Beuschel, Marta Maglione, Tanja Matkovic-Rachid, Sheng Huang, Martin Lehmann, Joerg RP Geiger & Stephan J Sigrist
J Neurogenet. 34(1):106-114 (2020)
Presynaptic activity zone plasticity encodes sleep need in Drosophila
Sheng Huang, Chengji Pia, Christine B Beuschel, Torsten Götz, Stephan J Sigrist
Curr Biol. 30(6):1077-1091.e5 (2020)
Network-specific synchronization of electrical slow-wave oscillations regulates sleep drive in Drosophila
Davide Raccuglia, Sheng Huang, Anatoli Ender, M.-Marcel Heim, Desiree Laber, Raquel Suárez-Grimalt, Agustin Liotta, Stephan J Sigrist, Jörg RP Geiger, David Owald
Curr Biol. 29(21):3611-3621.e3 (2019)
Autophagy within the mushroom body protects from synapse aging in a non-cell autonomous manner
Anuradha Bhukel, Christine B Beuschel, Marta Maglione, Martin Lehmann, Gabor Juhász, Frank Madeo and Stephan J Sigrist
Nat Commun. 10(1):1318 (2019)

Projects

A08

Publications

Homeostatic active zone remodeling consolidates memories in the Drosophila mushroom body

Presynaptic and postsynaptic long-term plasticity in sleep homeostasis

Recruitment of release sites underlies chemical presynaptic potentiation at hippocampal mossy fiber boutons

Unc13A and Unc13B contribute to the decoding of distinct sensory information in Drosophila

eIF5A-hypusination, boosted by dietary spermidine, protects from premature brain aging and mitochondrial dysfunction

The Unc13A isoform is important for phasic release and olfactory memory formation at mushroom body synapses

Presynaptic activity zone plasticity encodes sleep need in Drosophila

Network-specific synchronization of electrical slow-wave oscillations regulates sleep drive in Drosophila

Autophagy within the mushroom body protects from synapse aging in a non-cell autonomous manner

Participating Institutions