A01

Local and long-range excitatory-inhibitory interactions in CA3 sharp-wave ripples and replay

Sharp-wave ripple (SWRs) complexes, generated in the hippocampus are key network events involved in memory consolidation. The underlying mechanisms, however, remain incompletely understood. To understand the emergence of ripple oscillations and replay events, we will focus on the interactions between distinct excitatory and inhibitory cell populations within the CA3 region. We will assess the necessity of a distinct excitatory cell population for SWRs, analyze the connectivity between excitatory and inhibitory populations and determine external inputs to the CA3. The quantificational analysis will guide the development of network models to simulate SWRs. In turn, predictions from our models will inform us as to which synaptic connections could be critical for SWRs and should be the focus of our experiments. Together our experimental and theoretical findings will give us a detailed understanding of the mechanisms underlying SWRs and replay of memories.

Image Poster excerpt showing model of interactions between pyramidal cells (red), PV+ basket cells (blue), and anti-SWR cells (green). Courtesy of Richard Kempter and Gaspar Cano

Archive – A01 (SFB1315/1)

Archive – A01 (SFB1315/2)

Graphical Abstract

Graphical Abstract – aims of the Work Packages 1 to 4: WP1 addresses the necessity of athorny CA3 pyramids in the generation of SPW-Rs. WP2 uses modeling and experiments to investigate excitatory-inhibitory interactions and their influence on ripple oscillations. WP3 uses models to investigate how specific assemblies of cells are selected for replay. WP4 investigates how external inputs onto athorny pyramids may influence cortical-hippocampal interactions.

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