C01

Development of molecular tools for manipulating and studying memory consolidation

The C01 project develops and shares cutting-edge molecular tools, such as optogenetics, viral vectors, and transcriptomic analysis, to identify and manipulate memory-encoding neurons. Collaborating with our CRC partners, we foster innovation by creating tailored tools rather than simply fulfilling service requests. Our efforts aim to facilitate the detailed exploration of memory storage and retrieval, by enhancing neural circuits research through morphological, molecular, and functional analyses.

Image Schematic overview of the three work packages of the C01 project – optogenetics, viral tools, and transcriptome readouts. Image by Thorsten Trimbuch, Johannes Vierock, Benjamin Rost.

Archive – C01 (SFB1315/1)

Archive – C01 (SFB1315/2)

Graphical Abstract

Graphical Abstract: WP1 will validate and adapt existing optogenetic tools and employ a pipeline from structure-function analysis to targeted expression and in vivo application for generating new optogenetic tools. WP2, as an integral part of the Charité viral core facility, will focus on the research and development of innovative viral tools for neural circuit tracing and rapid transgene expression. WP3 will provide analytical tools for deciphering single cell transcriptomes at high resolution. Collaborations are indicated on the right.

Team

Publications

Participating Institutions